The Role of Epigenetics in the Formation of Serial Killers: Nature vs. Nurture

Authors

  • Joyce Lin Pacific American School
  • Mr. Bose
  • Dr. Roy

DOI:

https://doi.org/10.47611/jsr.v13i1.2394

Keywords:

Serial Killers, Epigenetics, Nature vs. Nurture

Abstract

This paper seeks to understand the origins of serial killers, examining the interplay between nature and nurture, particularly within the context of the "Golden Age of Serial Killers" in the late 20th century. By considering both genetic predispositions and environmental influences, this research takes into account the intriguing question of why so many famous American serial killers emerged during that time. It delves into the emerging field of epigenetics, which explores changes in gene expression influenced by environmental factors like stress, trauma, and exposure to toxins. Using in-depth analysis of multiple case studies and grounded theory method, the paper focuses on three case studies (David Berkowitz, Aileen Wuornos, and John Wayne Gacy) and investigates the potential epigenetic changes that may have heightened their risk of mental disorders and led them down the path of serial killing. Through this exploration, the study sheds light on the complex relationship between biology and environment in shaping criminal behavior and advocates for future research to mitigate the effects of epigenetic modifications on mental health and reduce the incidence of violent crime.

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References or Bibliography

Answer Brief of Appellee, State of Florida v. Aileen Wuornos." Supreme Court of Florida,

Nov. 2000, https://supremecourt.flcourts.gov/content/download/341430/file/00-1199_ans.pdf

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental

disorders (5th ed.).

"Aileen Wuornos." (n.d.). Biography.com. Retrieved from

https://www.biography.com/crime-figure/aileen-wuornos

"Aileen Wuornos Serial Killer." (n.d.). Florida Department of Law Enforcement. Retrieved

from https://www.fdle.state.fl.us/MSA/Content/Innocents/Aileen-Wuornos.aspx

Bevilacqua, L., Carli, V., & Sarchiapone, M. (2017). Genetic and environmental factors in

aggression: The role of the MAOA gene. Journal of Psychiatric Research, 92, 125-132. doi: 10.1016/j.jpsychires.2017.03.013

Bortolato, M., Pivac, N., & Muck-Seler, D. (2013). The effect of genetic and environmental

factors on antisocial behavior in children. Frontiers in Psychiatry, 4, 57. doi: 10.3389/fpsyt.2013.00057

Broidy, L. M., Nagin, D. S., Tremblay, R. E., Bates, J. E., Brame, B., Dodge, K. A., ... &

Vitaro, F. (2003). Developmental trajectories of childhood disruptive behaviors and adolescent delinquency: A six-site, cross-national study. Developmental psychology, 39(2), 222.

Berkowitz, D. (1997). Son of Sam: A biography of David Berkowitz. Columbia University

Press.

Bertsch, K., Roelofs, K., Roch, P. J., Ma, B., & Tuschen-Caffier, B. (2018).

Psychophysiological and epigenetic correlates of imagined affective interference during a Stroop task in borderline personality disorder. Psychoneuroendocrinology, 91, 69-76. doi: 10.1016/j.psyneuen.2018.02.020

"Broomfield, N., & Churchill, N. (Producers/Directors). (2003). Aileen: Life and death of a

serial killer [Motion picture]. United States: Columbia TriStar Home Video.

Bryant, Sarah. "John Wayne Gacy's Criminal Convictions for Assault and Battery." 5 May

, unpublished manuscript.

Charmaz, K. (2014). Constructing Grounded Theory. Sage.

Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton,

R. (2002). Role of genotype in the cycle of violence in maltreated children. Science, 297(5582), 851-854. doi: 10.1126/science.1072290

Dodge, K. A., Bates, J. E., & Pettit, G. S. (1990). Mechanisms in the cycle of violence.

Science, 250(4988), 1678-1683.

DiGangi, J. A., et al. (2013). "Impact of prior trauma on physical health following terrorist

attacks." Journal of Traumatic Stress 26(1): 134-141. doi: 10.1002/jts.21766

"David Berkowitz (a.k.a. Son of Sam)" on Biography.com:

https://www.biography.com/crime-figure/david-berkowitz

"David Berkowitz: The Son of Sam" on Crime Museum:

https://www.crimemuseum.org/crime-library/serial-killers/david-berkowitz-son-sam/

Dempster, E. L., Pidsley, R., Schalkwyk, L. C., & Mill, J. (2011). Epigenetic and genetic

variation at the IGF2/H19 imprinting control region on 11p15. 5 is associated with cerebellum weight. Epigenetics, 6(3), 413-417.

Dammann, G., & Jensen, C. M. (2014). Epigenetic programming of the stress response in

male and female rats by prenatal restraint stress. Brain Research, 1546, 62-71. https://doi.org/10.1016/j.brainres.2013.12.007

Douglass, J. E., Ressler, R. K., Burgess, A. W., & Hartman, C. R. (1986). Criminal profiling

from Crime Scene Analysis. Behav. Sci. Law, 4(4), pp. 401-421.

https://doi.org/10.1002/bsl.2370040405.

Federal Bureau of Investigation. (2020). Serial Murder. FBI.

https://www.fbi.gov/stats-services/publications/serial-murder

"Famous Cases & Criminals: John Wayne Gacy." (n.d.). FBI. Retrieved from

https://www.fbi.gov/history/famous-cases/john-wayne-gacy

Felitti, V. J., Anda, R. F., Nordenberg, D., Williamson, D. F., Spitz, A. M., Edwards, V., ... &

Marks, J. S. (1998). Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: The Adverse Childhood Experiences (ACE) Study. American Journal of Preventive Medicine, 14(4), 245-258.

Gudlowski, Y., Schecklmann, M., Grieger, F., Lemke, M. R., Pauli, P., & Ellgring, H. (2014).

Decreased activity and distinct methylation patterns of selected neurotransmitter receptor genes in the prefrontal cortex of aggressive individuals with antisocial personality disorder. Journal of Clinical Psychiatry, 75(2), 151-160. https://doi.org/10.4088/JCP.13m08413

Glaser, B. G., & Strauss, A. L. (1967). The discovery of grounded theory: Strategies for

qualitative research. Chicago: Aldine Publishing.

Hanson, J. L., Adluru, N., Chung, M. K., Alexander, A. L., Davidson, R. J., & Pollak, S. D.

(2010). Early neglect is associated with alterations in white matter integrity and cognitive functioning. Child development, 81(1), 167-183.

Holmes, R. M., & DeBurger, J. (1988). Serial murder. Newbury Park, CA: Sage Publications.

Herrenkohl, R. C., Hong, S., Klika, J. B., Herrenkohl, E. C., & Russo, M. J. (2008).

Developmental impacts of child abuse and neglect related to adult mental health, substance use, and physical health. Journal of family violence, 23(8), 437-445.

Hickey, E. W. (2010). Serial murderers and their victims (6th ed.). Belmont, CA: Wadsworth.

Holmes, R. M., & Holmes, S. T. (2009). Theoretical approaches to serial murder: A critique.

In J. A. Fox & J. L. Levin (Eds.), The Will to Kill: Making Sense of Senseless Murder (pp. 3-21). Boston: Allyn and Bacon.

"John Wayne Gacy." (n.d.). The Biography.com website. Retrieved from

https://www.biography.com/crime-figure/john-wayne-gacy

Kim, J. H., Kim, J. Y., Kim, K., Lee, H. J., Han, P. L., & Park, H. J. (2008). Epigenetic

modulation of brain-derived neurotrophic factor during development and synaptic plasticity. The Journal of biological chemistry, 283(9), 6049-6055

Kinoshita, M., Numata, S., Tajima, A., Shimodera, S., Imoto, I., Sasaki, T., ... & Ohmori, T.

(2013). Aberrant DNA methylation of blood in schizophrenia by adjusting for estimated cellular proportions. Neuropsychopharmacology, 38(5), 734-742.

Keppel, R. D., & Birnes, W. J. (2003). Signature Killers: Interpreting the Calling Cards of the Serial

Murderer. Pocket Books.

Linedecker, C. (1993). Killer clown: The John Wayne Gacy murders. St. Martin's Paperbacks.

Ramsland, K. (2017, March 3). Inside the mind of a killer clown. Psychology Today. https://www.psychologytoday.com/us/blog/shadow-boxing/201703/inside-the-mind-killer-clown

Linedecker, C. (1992). The Man Who Killed Boys: The John Wayne Gacy, Jr. Story. St.

Martin's True Crime Classics.

Leichsenring, F., Leibing, E., Kruse, J., New, A. S., & Leweke, F. (2011). Borderline

personality disorder. The Lancet, 377(9759), 74-84. doi: 10.1016/S0140-6736(10)61422-5

Leyton, E. (2013). Hunting Humans: The Rise of the Modern Multiple Murderer. McClelland

& Stewart.

Moffitt, T. E., Caspi, A., Rutter, M., & Silva, P. A. (2003). Sex differences in antisocial

behaviour: Conduct disorder, delinquency, and violence in the Dunedin Longitudinal Study. Cambridge University Press.

McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., ... &

Meaney, M. J. (2009). Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature neuroscience, 12(3), 342-348. doi: 10.1038/nn.2270

McCrory, E. J., De Brito, S. A., & Viding, E. (2011). Research review: the neurobiology and

genetics of maltreatment and adversity. Journal of Child Psychology and Psychiatry, 52(10), 999-1015.

McLaughlin, K. A., Sheridan, M. A., & Lambert, H. K. (2015). Childhood adversity and

neural development: Deprivation and threat as distinct dimensions of early experience. Neuroscience & Biobehavioral Reviews, 47, 578-591.

Mehta, D., Klengel, T., Conneely, K. N., Smith, A. K., Altmann, A., Pace, T. W., ... &

Ressler, K. J. (2013). Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder. Proceedings of the National Academy of Sciences, 110(20), 8302-8307.

Mills, J., Bonner, A., & Francis, K. (2006). The development of constructivist grounded

theory. International Journal of Qualitative Methods, 5(1), 1-10. doi: 10.1177/160940690600500101

Masters, B. (2019). John Wayne Gacy: The man who killed boys. Penguin Random House

Mill, J., & Petronis, A. (2008). Pre- and peri-natal environmental risks for attention-deficit

hyperactivity disorder (ADHD): The potential role of epigenetic processes in mediating susceptibility. Journal of Child Psychology and Psychiatry, 49(10), 1020-1030. https://doi.org/10.1111/j.1469-7610.2008.01908.x

Palma-Gudiel, H., Córdova-Palomera, A., E

Perera, F., Herbstman, J., Prenatal Environmental Exposures, Bisphenol A and Genital

Anomalies. In: Present and Future of Pediatric Surgery. 2009:45-58. doi: 10.1007/978-88-470-0726-1_5.

Provencal, N., et al. "The Signature of Maternal Rearing in the Methylome in Rhesus Macaque

Prefrontal Cortex and T Cells." Journal of Neuroscience, vol. 32, no. 44, 2012, pp. 15626-15642.

Ressler, R. K., Burgess, A. W., & Douglas, J. E. (1988). Sexual homicide: Patterns and

motives. Lanham, MD: Lexington Books.

Ressler, R. K., Burgess, A. W., & Douglas, J. E. (1992). Sexual Homicide: Patterns and Motives. Free

Press.

Senut, M. C., Cingolani, P., Sen, A., Kruger, A., Shaik, A., Hirsch, H., ... & Burns, P. (2012).

Lead exposure disrupts global DNA methylation in human embryonic stem cells and alters their neuronal differentiation. Toxicological Sciences, 125(1), 183-193. doi: 10.1093/toxsci/kfr261

Stenz, L., Schechter, D. S., Serpa, S. R., Paoloni-Giacobino, A., & Ehlert, U. (2019).

Epigenetics of attachment trauma: Differential DNA methylation of genes involved in oxytocin signaling and stress regulation in borderline personality disorder. Frontiers in Human Neuroscience, 13, 98. doi: 10.3389/fnhum.2019.00098

"Son of Sam" on FBI.gov: https://www.fbi.gov/history/famous-cases/son-of-sam

Schechter, H. (2003). The Serial Killer Files: The Who, What, Where, How, and Why of the

World's Most Terrifying Murderers. Ballantine Books.

Sullivan, T., & Maiken, P. (1986). Killer Clown: The John Wayne Gacy Murders. New York,

NY: Pinnacle Books.

Salinger, L. (2013). Son of Sam: The infamous serial killer who terrorized New York.

Skyhorse Publishing, Inc.

Schofield, E. (2017). The relationship between childhood trauma and personality disorder

traits in adults: A systematic review. Journal of Trauma & Dissociation, 18(5), 567-581.

Smith, K. (2018). Epigenetics of antisocial personality disorder: Current findings and future

directions. Journal of Forensic Psychology Research and Practice, 18(3), 187-198.

Tresniowski, A. (2016, August 8). Inside the mind of the Son of Sam killer 40 years after his

arrest. People. Retrieved from https://people.com/crime/son-of-sam-killer-david-berkowitz-40th-anniversary/

Turecki, G., & Meaney, M. J. (2016). Effects of the social environment and stress on

glucocorticoid receptor gene methylation: a systematic review. Biological psychiatry, 79(2), 87-96.

Tielbeek, J. J., Johansson, A., Polderman, T. J., Rautiainen, M. R., Jansen, P., Taylor, M.,

Tong, X., Lu, Q., Burt, A. S., Tiemeier, H., Viding, E., Plomin, R., Martin, N. G., Heath, A. C., Madden, P. A., Montgomery, G. W., Beaver, K. M., Waldman, I. D., Gelernter, J., & Posthuma, D. (2017). Genome-wide association studies of a broad spectrum of antisocial behavior. JAMA Psychiatry, 74(12), 1242-1250.

Takayama, K., Takahashi, Y., Tsuchiya, K. J., Matsumoto, K., & Suzuki, K. (2020).

Epigenetic alterations in the brains of forensic autopsy cases with psychiatric disorders and/or substance use histories. PLoS One, 15(3), e0229763. doi: 10.1371/journal.pone.0229763

"The Son of Sam Case: A Timeline" on History.com:

https://www.history.com/this-day-in-history/the-son-of-sam-case-a-timeline

Vorpagel, J.E. (1999). John Wayne Gacy: The Killer Clown. Retrieved from

https://www.trutv.com/library/crime/serial_killers/notorious/gacy/childhood_2.html

Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R.,

Dymov, S., Szyf, M., & Meaney, M. J. (2004). Epigenetic programming by maternal behavior. Nature Neuroscience, 7(8), 847-854. doi: 10.1038/nn1276

Weaver, I. C., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., ... & Meaney,

M. J. (2004). Epigenetic programming by maternal behavior. Nature Neuroscience, 7(8), 847-854.

Weight, F. F., Bacon, B. R., & Sandstead, H. R. (2010). Lead alters plasma and erythrocyte

membrane calcium and sodium transport in the rat. Environmental research, 52(2), 162-170. doi: 10.1016/0013-9351(90)90003-y

Wilson, L. C., & Scarpa, A. (2011). The association between abuse and psychopathy: A

review of the literature. Aggression and Violent Behavior, 16(4), 289-299.

Widom, C. S., Czaja, S. J., & Dutton, M. A. (2015). Childhood victimization and the

development of personality disorders. In M. L. Benson & F. M. Richman (Eds.), Crime and the life course: An introduction (2nd ed., pp. 213-232). Routledge.

Wilson, R. J., & Seaman, C. A. (2019). The handbook of forensic psychology (5th ed.).

Hoboken, NJ: John Wiley & Sons.

Wisdom, C. & Mayfield, J. (2001). Childhood victimization: Early adversity, later

psychopathology. National Institute of Justice Journal, 248, 12-19.

Ziegler, C., Richter, J., Mahr, M., Gajewska, A., Schiele, M. A., Gehrmann, L., ... &

Winterer, G. (2016). MAOA gene hypomethylation in panic disorder—reversibility of an epigenetic risk pattern by psychotherapy. Translational psychiatry, 6(10), e773-e773. doi: 10.1038/tp.2016.172

Published

02-29-2024

How to Cite

Lin, J., Bose, J. K., & Roy, T.-A. . (2024). The Role of Epigenetics in the Formation of Serial Killers: Nature vs. Nurture. Journal of Student Research, 13(1). https://doi.org/10.47611/jsr.v13i1.2394

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Review Articles